The special issue is dedicated to the 270th anniversary of Lomonosov Moscow State University. Our article provides an overview of the work from our group conducted using the resources of the MSU Supercomputing Center. Ref

The paper "Synthesis and Evaluation of Tetrahydropyrrolo[1,2-a]quinolin-1(2H)-ones as New Tubulin Polymerization Inhibitors" will appear in RSC Medicinal Chemistry.
Please, check it out in our first lab preprint: ChemRxiv

This summer, our lab had the opportunity to participate in two scientific meetings, where we shared our research through poster presentations.
In July, Nikita attended the IUPAB Congress 2024 in Kyoto, Japan. He presented our recent theoretical work on the kinetochore complex NDC80, as well as a study on microtubule catastrophes and rescues.
Later, Nikita, along with Mikhail and Ilya, attended the 6th Russian Conference on Medicinal Chemistry in Nizhny Novgorod. All presented posters on the methodologies we've been developing to study tubulin-drug interactions.
We’re pleased to have been able to contribute to these conferences and to connect with others in the field.

This year the meeting will be devoted to the Cytoskeleton. The program of the conference includes talks from Russian and international specialists in the fields of cellular motility, muscle contraction, tubulin cytoskeleton and cell division.

The lecture will take place at 17:00 on November 16 in the central auditorium of the Physics Deparment of Lomonosov Moscow State University. The lecture is open to the students and faculty of the Moscow State University.

Our work on "Microtubule rescue control by drugs and MAPs examined with in vitro pedestal assay" is available online as a part of the Special Issue of the European Journal of Cell Biology on "In vitro reconstitution of cytoskeletal processes"

This review is devoted to measuring and modeling forces generated by microtubules. The full text is here

We are happy to report that the past 5 days were quite intense, productive and successful. Together with 12 great students we performed gene cloning, transformation of bacterial cells, IPTG-induced gene expression and protein purification. As a result, three beautiful fluorescent proteins were produced and isolated.

The defence of the thesis entitled "Microtubule dynamics and the mechanism of chromosome transport during cell division" (in Biophysics) took place at the Physics Department of Lomonosov Moscow State University. An excellent microtubule cake was awarded and eaten together

We were lucky to make our modest contribution to the extensive study conducted by chemists at Moscow State University and Florida State University, USA: Expanding Stereoelectronic Limits of endo-tet Cyclizations: Synthesis of Benz[b]azepines from Donor-Acceptor Cyclopropanes. Our contribution to this work was to determine the effects of completely new compounds synthesized for this study on the microtubules dynamics in vitro.
The author of the picture below is Maria Andreeva

In this work, we tried to address issues related to the physiology of a wide range of processes associated with the microtubule dynamics, and to formulate modern ideas about the mechanisms and regulation of the microtubules dynamics in cells and artificial systems:Regulation of microtubule dynamics, mechanics and function through the growing tip

Our paper is on December cover!

The conference was especially enjoyable and long-awaited as it was the first opportunity to meet face-to-face with scientists from all over the world since the outbreak of the pandemic.
Special congratulations to Veronika Alexandrova, who received the Biophysical Society award for the best poster presentation!
Mikhail Anisimov and Iuliia Lopanskaya have received EBSA Travel Awards

We have shown that the unstructured C-tails of alpha-tubulin can directly regulate microtubule dynamics. Detyrosination of alpha-tubulin C-tails affects microtubules only indirectly, modulating the binding of regulatory protein CLIP-170 to the microtubules. Below is a video showing the calculation results of the interaction between alpha-tubulin C-tail and its globule. On the left is a picture drawn by a first author, Jiayi Chen, of comets formed by plus-end binding proteins, presented on the cover of Dev Cell!

Congratulations to Mikhail Anisimov and Nikita Gudimchuk, who took the second place in the "Biomolecula" contest with the article "Zoo of tubulin inhibitors".

An article on statistical processing of biological data titled Avoiding common problems with statistical analysis of biological experiments using a simple nested data simulator is published in a journal of Systems Biology and Physiology Reports